MKI67 Antibody

ArtNr	OACD04969
Hersteller	AVIVA Systems Biology
Menge	100 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Neural Development Antibodies By Cell Type Blastoma Carcinoma Hematology Lymphoma Cell Biology Cell Status Immunohistochemistry Immunoprecipitation Western Blot ELISA Immunofluorescence Immunocytochemistry Proliferation Viability Primary Antibodies By Organ Lung Cancer Bladder Cancer Breast Cancer Testicular & Prostate Cancer Adhesion Molecule Markers Cytoskeleton Markers Immunochemistry
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IP, IHC, ICC
Specific against	Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	antigen identified by monoclonal antibody Ki-67 homolog;antigen Ki67 homolog;antigen KI-67 homolog;D630048A14Rik;Ki6;Ki-6;Ki67;Ki-67;proliferation marker protein Ki-67.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	WB: 0.5-2 ug/mLIHC: 5-20 ug/mLICC: 5-20 ug/mLOptimal dilutions should be determined by end user.
Gene symbol	Mki67
Gene Fullname	antigen identified by monoclonal antibody Ki 67
Product format	Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Reconstitution and storage	2°C to 8°C\|-20°C
Description of target	Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (By similarity). Does not contribute to the internal structure of mitotic chromosomes (PubMed:26949251). May play a role in chromatin organization (PubMed:26949251). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed.
Nucleotide accession_num	NM_001081117
Protein accession_num	NP_001074586.2
Protein name	Proliferation marker protein Ki-67
Clonality	Polyclonal
Purification	Affinity Purified; Protein A Purified
Immunogen	Recombinant Ki-67 (Met1~Cys247) expressed in E.coli
Manufacturer - Specificity	The antibody is a rabbit polyclonal antibody raised against Ki67P. It has been selected for its ability to recognize Ki67P in immunohistochemical staining and western blotting.
Concentration	0.5 mg/ml

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Menge: 100 ul

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