IGF2BP3 Antibody (OAEC04704)

Wet Ice

Ascitic fluid containing 0.03% sodium azide

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in R NA binding and are known to be involved in RNA synthesis and metabolism.Tissue specificity Expressed in fetal liver, fetal lung, fetal kidney, fetal thym us, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes , spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in tes ticular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expres sed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines.IMP-3 is a marker for carcinomas and high-grade dys plastic lesions of pancreatic ductal epithelium.

Purified recombinant fragment of human IGF2BP3 expres sed in E. Coli.