CD14 Antibody

ArtNr	OAEE00636
Hersteller	AVIVA Systems Biology
Menge	100 tests (T100)
Kategorie	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Antibodies By Cell Type Hematology Leukemia Lymphoma Flow Cytometry Immunohistochemistry Immunoprecipitation ELISA Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	FC
Clon	MEM-15
Specific against	Human (Homo sapiens), Primate
Host	Mouse
Isotype	IgG1
Konjugat/Tag	APC
Citations	Schiff DE, Rae J, Martin TR, Davis BH, Curnutte JT: Increased phagocyte Fc gammaRI expression and improved Fc gamma-receptor-mediated phagocytosis after in vivo recombinant human interferon-gamma treatment of normal human subjects. Blood. 1997 Oct 15;90(8):3187-94. Sing A, Rost D, Tvardovskaia N, Roggenkamp A, Wiedemann A, Kirschning CJ, Aepfelbacher M, Heesemann J: Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppression. J Exp Med. 2002 Oct 21;196(8):1017-24. Funda DP, TuckovÃ¡ L, FarrÃ© MA, Iwase T, Moro I, TlaskalovÃ¡-HogenovÃ¡ H: CD14 is expressed and released as soluble CD14 by human intestinal epithelial cells in vitro: lipopolysaccharide activation of epithelial cells revisited. Infect Immun. 2001 Jun;69(6):3772-81. Bazil V, Horejsi V, Baudys M, Kristofova H, Strominger JL, Kostka W, Hilgert I.: Biochemical characterization of a soluble form of the 53-kDa monocyte surfaceantigen. Eur J Immunol. 1986 Dec;16(12):1583-9. Leukocyte Typing IV., Knapp W. et al. (Eds.), Oxford University Press (1989). Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997). Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995). Leukocyte Typing III., McMichael A. J. et al (Eds.), Oxford University Press (1987). FernÃ¡ndez-Real JM, Broch M, Richart C, Vendrell J, LÃ³pez-Bermejo A, Ricart W: CD14 monocyte receptor, involved in the inflammatory cascade, and insulinsensitivity. J Clin Endocrinol Metab. 2003 Apr;88(4):1780-4. Asai Y, Makimura Y, Kawabata A, Ogawa T: Soluble CD14 Discriminates Slight Structural Differences between Lipid As That Lead to Distinct Host Cell Activation. J Immunol. 2007 Dec 1;179(11):7674-83. Lodrup Carlsen KC, Granum B: Soluble CD14: role in atopic disease and recurrent infections, including otitismedia. Curr Allergy Asthma Rep. 2007 Nov;7(6):436-43. Juan TS, Hailman E, Kelley MJ, Wright SD, Lichenstein HS: Identification of a domain in soluble CD14 essential for lipopolysaccharide (LPS) signaling but not LPS binding. J Biol Chem. 1995 Jul 21;270(29):17237-42.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	monocyte differentiation antigen CD14;myeloid cell-specific leucine-rich glycoprotein.
Versandbedingung	Gekühlt
Lieferbar
Specificity	Human, Non-human Primate
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Gene symbol	CD14
Gene Fullname	CD14 molecule
Product format	Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Reconstitution and storage	2°C to 8°C
Description of target	Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187).
Nucleotide accession_num	NM_000591.3; NM_001040021.2; NM_001174104.1; NM_001174105.1
Protein accession_num	NP_000582.1; NP_001035110.1; NP_001167575.1; NP_001167576.1
Protein name	Monocyte differentiation antigen CD14
Clonality	Monoclonal
Purification	Purified by size-exclusion chromatography
Immunogen	A crude mixture of human urinary proteins precipitated by ammonium sulphate from the urine of a patient suffering from proteinuria.
Manufacturer - Specificity	The antibody MEM-15 reacts with CD14, a 53-55 kDa GPI (glycosylphosphatidylinositol)-linked membrane glycoprotein expressed on monocytes, macrophages and weakly on granulocytes; also expressed by most tissue macrophages. The antibody MEM-15 also reacts with soluble forms of CD14 found in serum and in the urine of some nephrotic patients. HLDA III; WS Code M 252 HLDA IV; WS Code M 113 HLDA IV; WS Code NL 90 HLDA IV; WS Code T 53 HLDA V; WS Code M MA086 HLDA VI; WS Code M MA94
Formulation	APC
Concentration	10 ul / test
Storage Buffer	The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.

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Menge: 100 tests (T100)

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