CD22 Antibody

ArtNr	OAEE00729
Hersteller	AVIVA Systems Biology
Menge	100 tests (T100)
Kategorie	Oncology Neuroscience Aging & Neurological Disorders Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Adenocarcinoma Flow Cytometry Immunoprecipitation Western Blot Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	FC
Clon	MEM-01
Specific against	Human (Homo sapiens), Primate
Host	Mouse
Isotype	IgG1
Konjugat/Tag	PE
Citations	Walker JA, Smith KG: CD22: an inhibitory enigma. Immunology. 2007 Dec 7 Tateno H, Li H, Schur MJ, Bovin N, Crocker PR, Wakarchuk WW, Paulson JC: Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity. Mol Cell Biol. 2007 Aug;27(16):5699-710. Tedder TF, Poe JC, Haas KM: CD22: A Multifunctional Receptor That Regulates B Lymphocyte Survival and Signal Transduction. Adv Immunol. 2005;88:1-50.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	B-cell receptor CD22;BL-CAM;B-lymphocyte cell adhesion molecule;CD22 antigen;sialic acid-binding Ig-like lectin 2;SIGLEC2;SIGLEC-2;T-cell surface antigen Leu-14.
Versandbedingung	Gekühlt
Lieferbar
Specificity	Human, Non-human Primate
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Manufacturer - Conjugate / Tag	R-PE
Shipping Temperature	Wet Ice
Gene symbol	CD22
Gene Fullname	CD22 molecule
Product format	Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Reconstitution and storage	2°C to 8°C
Description of target	Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Nucleotide accession_num	NM_001185099.1; NM_001185100.1; NM_001185101.1; NM_001278417.1; NM_001771.3
Protein accession_num	NP_001172028.1; NP_001172029.1; NP_001172030.1; NP_001265346.1; NP_001762.2
Protein name	B-cell receptor CD22
Clonality	Monoclonal
Purification	Purified by size-exclusion chromatography
Immunogen	Raji Burkitt's lymphoma cell line
Manufacturer - Specificity	The antibody MEM-01 reacts with CD22 (BL-CAM), a 130 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes; it is lost on plasma cells, peripheral blood T lymphocytes, granulocytes and monocytes. The antibody MEM-01 cross-blocks the antibody OTH228 that recognizes uniquely epitope "E"; it does not cross-block antibodies RFB-4, CLB22/1 and CLB-BLy1.
Formulation	PE
Concentration	20 ul / test
Storage Buffer	The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.

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Menge: 100 tests (T100)

lieferbar

Lieferung vsl. bis 08.01.2026

Express-Lieferung: 7 Tage sparen

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