TNFRSF8 Antibody

ArtNr	OAEE00796
Hersteller	AVIVA Systems Biology
Menge	100 tests (T100)
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Antibodies By Cell Type Hematology Leukemia Lymphoma Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis Mesothelioma Flow Cytometry Immunohistochemistry Western Blot ELISA Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	FC
Clon	MEM-268
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG
Konjugat/Tag	PE
Citations	Pavlov I, Martins TB, Delgado JC: Development and validation of a fluorescent microsphere immunoassay for soluble CD30 testing. Clin Vaccine Immunol. 2009 Sep;16(9):1327-31. Wright CW, Rumble JM, Duckett CS: CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells. J Biol Chem. 2007 Apr;282(14):10252-62. Zeiser R, Nguyen VH, Hou JZ, Beilhack A, Zambricki E, Buess M, Contag CH, Negrin RS: Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatoryT cells in prevention of acute graft-versus-host disease. Blood. 2007 Mar 1;109(5):2225-33. Kusanovic JP, Romero R, Hassan SS, Gotsch F, Edwin S, Chaiworapongsa T, Erez O, Mittal P, Mazaki-Tovi S, Soto E, Than NG, Friel LA, Yoon BH, Espinoza J: Maternal serum soluble CD30 is increased in normal pregnancy, but decreased in preeclampsia and small for gestational age pregnancies. J Matern Fetal Neonatal Med. 2007 Aug 28;:1-12 Bekiaris V, Withers D, Glanville SH, McConnell FM, Parnell SM, Kim MY, Gaspal FM, Jenkinson E, Sweet C, Anderson G, Lane PJ: Role of CD30 in B/T segregation in the spleen. J Immunol. 2007 Dec 1;179(11):7535-43. Polte T, Behrendt AK, Hansen G: Direct evidence for a critical role of CD30 in the development of allergicasthma. J Allergy Clin Immunol. 2006 Oct;118(4):942-8. Kennedy MK, Willis CR, Armitage RJ: Deciphering CD30 ligand biology and its role in humoral immunity. Immunology. 2006 Jun;118(2):143-52. Fischer M, Harvima IT, Carvalho RF, MÃ¶ller C, Naukkarinen A, Enblad G, Nilsson G: Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion. J Clin Invest. 2006 Oct;116(10):2748-56. Blazar BR, Levy RB, Mak TW, Panoskaltsis-Mortari A, Muta H, Jones M, Roskos M, Serody JS, Yagita H, Podack ER, Taylor PA: CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host disease. J Immunol. 2004 Sep 1;173(5):2933-41.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	CD30;CD30L receptor;cytokine receptor CD30;D1S166E;Ki-1;Ki-1 antigen;lymphocyte activation antigen CD30;tumor necrosis factor receptor superfamily member 8.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Manufacturer - Conjugate / Tag	R-PE
Shipping Temperature	Wet Ice
Gene symbol	TNFRSF8
Gene Fullname	TNF receptor superfamily member 8
Product format	Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Reconstitution and storage	2°C to 8°C
Description of target	Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
Nucleotide accession_num	NM_001243.4; NM_001281430.2
Protein accession_num	NP_001234.3; NP_001268359.2
Protein name	Tumor necrosis factor receptor superfamily member 8
Clonality	Monoclonal
Purification	Purified by size-exclusion chromatography
Immunogen	Expression vector containing CD30 cDNA (booster suspension of THP-1 cell line)
Manufacturer - Specificity	The antibody MEM-268 recognizes extracellular part of CD30 (Ki-1 antigen), a 105 kDa single chain glycoprotein expressed on Hodgkin's and Reed-Sternberg cells; it is also found in Burkitt's lymphomas, virus-infected T and B lymphocytes, and on normal B and T lymphocytes after activation (T lymphocytes that produce Th2-type cytokines and on CD4+/CD8+ T lymphocytes that co-express CD45RO and the IL4 receptor).
Formulation	PE
Concentration	20 ul / test
Storage Buffer	The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.

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Menge: 100 tests (T100)

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