C5AR1 Antibody

ArtNr	OAEE00993
Hersteller	AVIVA Systems Biology
Menge	100 tests (T100)
Kategorie	Neuroscience Neural Lineage Markers Neuroinflammation Antibodies Flow Cytometry Immunohistochemistry Immunoprecipitation Western Blot Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	FC
Clon	S5/1
Specific against	Human (Homo sapiens), Rabbit (Oryctolagus cuniculus), Ferret, Cattle (Bovine)
Host	Mouse
Isotype	IgG2a
Konjugat/Tag	PE
Citations	Camous L, Roumenina L, Bigot S, Brachemi S, FrÃ©meaux-Bacchi V, Lesavre P, Halbwachs-Mecarelli L: Complement alternative pathway acts as a positive feedback amplification of neutrophil activation. Blood. 2011 Jan 27;117(4):1340-9. Cain SA, Monk PN: The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74). J Biol Chem. 2002 Mar 1;277(9):7165-9. Conway Morris A, Kefala K, Wilkinson TS, Dhaliwal K, Farrell L, Walsh T, Mackenzie SJ, Reid H, Davidson DJ, Haslett C, Rossi AG, Sallenave JM, Simpson AJ: C5a mediates peripheral blood neutrophil dysfunction in critically ill patients. Am J Respir Crit Care Med. 2009 Jul 1;180(1):19-28. Kiener HP, Baghestanian M, Dominkus M, Walchshofer S, Ghannadan M, Willheim M, Sillaber C, Graninger WB, Smolen JS, Valent P: Expression of the C5a receptor (CD88) on synovial mast cells in patients with rheumatoid arthritis. Arthritis Rheum. 1998 Feb;41(2):233-45.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	C5A;C5a anaphylatoxin chemotactic receptor;C5a anaphylatoxin chemotactic receptor 1;C5a anaphylatoxin receptor;C5a ligand;C5a-R;C5AR;C5R1;CD88;complement component 5a receptor 1.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Manufacturer - Conjugate / Tag	R-PE
Shipping Temperature	Wet Ice
Gene symbol	C5AR1
Gene Fullname	complement C5a receptor 1
Product format	Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Reconstitution and storage	2°C to 8°C
Description of target	Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).
Nucleotide accession_num	NM_001736.3
Protein accession_num	NP_001727.1
Protein name	C5a anaphylatoxin chemotactic receptor 1
Clonality	Monoclonal
Purification	Purified by size-exclusion chromatography
Immunogen	Recombinant N-terminal peptide (Asp15-Asp27) of human C5aR
Manufacturer - Specificity	The mouse monoclonal antibody S5/1 recognizes the CD88 protein, a 43 kDa receptor of C5a component of the complement cascade.
Formulation	PE
Concentration	10 ul / test
Storage Buffer	The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.

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Menge: 100 tests (T100)

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