MYC Antibody (OAGA02148)

Wet Ice

Liquid. 1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt' s lymphomas, suggesting its importance in the normal function of this gene.

Purified by antigen-affinity chromatography.