MCM6 Antibody

ArtNr	OAGA07431
Hersteller	AVIVA Systems Biology
Menge	100 ul
Kategorie	Neuroscience Neural Lineage Markers Antibodies Immunohistochemistry Immunoprecipitation Western Blot Immunofluorescence Immunocytochemistry Primary Antibodies CHiP Immunochemistry
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, IP, ICC, IHC-P, CHIP
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Mis5,P105MCM,MCG40308
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Polyclonal Antibody
Manufacturer - Category	Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Wet Ice
Manufacturer - Application Additional Information	Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IHC-P, IP: 1:100-1:500, WB: 1:500-1:3000, ChIP assay. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Gene symbol	MCM6
Gene Fullname	minichromosome maintenance complex component 6
Product format	Liquid
Reconstitution and storage	Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Description of target	The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood.
Nucleotide accession_num	NM_005915.5
Protein accession_num	NP_005906.2
Protein name	DNA replication licensing factor MCM6
Clonality	Polyclonal
Purification	Purified by antigen-affinity chromatography.
Immunogen	Recombinant protein encompassing a sequence within the C-terminus region of human MCM6. The exact sequence is proprietary.
Concentration	1 mg/ml
Storage Buffer	1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

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