TSC22D3 Antibody - N-terminal

Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot

Wet Ice

TSC22D3

Liquid. TSC22D3 Antibody is supplied in PBS containing 0.02% sodium azide.

Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).

https://www.ncbi.nlm.nih.gov/protein/NP_932174

Polyclonal

Rabbit polyclonal TSC22D3 antibody was raised against a 16 amino acid peptide near the amino terminus of human TSC22D3. The immunogen is located within amino acids 40 - 90 of TSC22D3.