GRK6 Antibody - C-terminal

Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot

Wet Ice

GRK6

Liquid. GRK6 antibody is supplied in PBS containing 0.02% sodium azide.

Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).

https://www.ncbi.nlm.nih.gov/protein/NP_001004106

Polyclonal

GRK6 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human GRK6. The immunogen is located within the last 50 amino acids of GRK6.