Anti-LGR4 Antibody

ArtNr	OARA03107
Hersteller	AVIVA Systems Biology
Menge	1 mg
Kategorie	Oncology Neuroscience Neural Lineage Markers Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Antibodies By Cell Type Carcinoma Obesity Immunohistochemistry Western Blot ELISA Lipoprotein Receptors & Associated Proteins Primary Antibodies Immunostaining
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Clon	6G8.B3.G5.C3
Specific against	Human (Homo sapiens), Monkey (Cynomolgus, Simian), Primate
Host	Mouse
Konjugat/Tag	Unconjugated
Dry ice	Yes
Citations	Weng,J., Luo,J., Cheng,X., Jin,C., Zhou,X., Qu,J., Tu,L., Ai,D.,Li,D., Wang,J., Martin,J.F., Amendt,B.A. and Liu,M.(2008) Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. Proc. Natl. Acad. Sci. U.S.A. 105 (16), 6081-6086.Gao,Y., Kitagawa,K., Hiramatsu,Y., Kikuchi,H., Isobe,T., Shimada,M., Uchida,C., Hattori,T., Oda,T., Nakayama,K., Nakayama,K.I., Tanaka,T., Konno,H. and Kitagawa,M. (2006) Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis. Cancer Res. 66 (24), 11623-11631.Loh,E.D., Broussard,S.R. and Kolakowski,L.F. (2001) Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor. Biochem. Biophys. Res. Commun. 282 (3), 757-764.Loh,E.D., Broussard,S.R., Liu,Q., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and Kolakowski,L.F. Jr. (2000) Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping. Cytogenet. Cell Genet. 89 (1-2), 2-5.Hsu,S.Y., Liang,S.G. and Hsueh,A.J. (1998) Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region. Mol. Endocrinol. 12 (12), 1830-1845.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	BNMD17;G protein-coupled receptor 48;GPR48;G-protein coupled receptor 48;leucine-rich repeat-containing G-protein coupled receptor 4.
Versandbedingung	Trockeneis
Lieferbar
Specificity	Chimpanzee, Human, Macaque
Manufacturer - Type	Monoclonal Antibody
Manufacturer - Category	Root Catalog/Products/Monoclonal Antibodies, Root Catalog/Products/Primary Antibodies
Shipping Temperature	Dry Ice
Manufacturer - Application Additional Information	ELISA: 1:20, 000 WB: 1:500-1:3, 000 IHC: 5 ug/mL
Gene symbol	LGR4
Gene Fullname	leucine rich repeat containing G protein-coupled receptor 4
Product format	Liquid (sterile filtered)
Reconstitution and storage	Store vial at -20 C or below prior to opening. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of opening.
Description of target	Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (By similarity).
Protein name	Leucine-rich repeat-containing G-protein coupled receptor 4
Clonality	Monoclonal
Immunogen	This LGR4 antibody was produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human LGR4 protein. The hybridoma was produced by fusing BALB/c mouse splenocytes and mouse myeloma SP2/O cells using conventional technology.
Concentration	1 mg/ml

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OARA03107-datasheet.pdf

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Menge: 1 mg

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Lieferung vsl. bis 08.01.2026

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