BNIP3 Antibody - middle region

Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies

22 kDa

BNIP3

Liquid.PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

BNIP-3 Polyclonal Antibody detects endogenous levels of BNIP-3 protein.