ITPK1 Antibody - middle region

Polyclonal Antibody

Acetylation by EP300 and CREBBP destabilizes ITPK1, and down-regulates enzymatic activity. Deacetylated by SIRT1.

50 kDa

ITPK1

Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3, 4, 5, 6)P4 or Ins(1, 3, 4)P3. Phosphorylates Ins(3, 4, 5, 6)P4 at position 1 to form Ins(1, 3, 4, 5, 6)P5. This reaction is thought to have regulatory importance, since Ins(3, 4, 5, 6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1, 3, 4, 5, 6)P5 is not. Also phosphorylates Ins(1, 3, 4)P3 on O-5 and O-6 to form Ins(1, 3, 4, 6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1, 3, 4, 5)P4 and Ins(1, 3, 4, 6)P4 to Ins(1, 3, 4)P3, and Ins(1, 3, 4, 5, 6)P5 to Ins(3, 4, 5, 6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1, 3, 4, 5)P4 and Ins(1, 3, 4, 6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ITPK1 Polyclonal Antibody detects endogenous levels of ITPK1 protein.