TP53I3 Antibody - C-terminal region

Root Catalog/Products/Polyclonal Antibodies, Root Catalog/Products/Primary Antibodies

36 kDa

TP53I3

Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

PIG3 Polyclonal Antibody detects endogenous levels of PIG3 protein.