BPIFA1 Antibody - middle region

Polyclonal Antibody

May be N-glycosylated.

27 kDa

BPIFA1

Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

PLUNC Polyclonal Antibody detects endogenous levels of PLUNC protein.