SNCA Antibody (Phospho-Tyr133)

Polyclonal Antibody

Phospho-Tyr133

50/15 kDa

SNCA

Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer' s disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Phospho-Synuclein- Alpha (Tyr133) Polyclonal Antibody detects endogenous levels of Synuclein- Alpha protein only when phosphorylated at Y133.