TEK Antibody (Phospho-Tyr992)

Polyclonal Antibody

Phospho-Tyr992

120 kDa

TEK

Liquid. PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Phospho-Tie-2 (Tyr992) Polyclonal Antibody detects endogenous levels of Tie-2 protein only when phosphorylated at Y992.