SNAPIN ELISA Kit (Human) (OKCD00523)

SNARE-associated protein Snapin

23557

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells.2 Publications < p>Manually curated information for which there is published experimental evidence.< /p> < p>< a href="/manual/evidences#ECO:0000269">Moreâa‚¬A< /a>< /p> Manual assertion based on experiment iniRef.10"BLOC-1 is required for cargo-specific sorting from vacuolar early endosomes toward lysosome-related organelles."_x005F_x000D_ Setty S.R., Tenza D., Truschel S.T., Chou E., Sviderskaya E.V., Theos A.C., Lamoreux M.L., Di Pietro S.M., Starcevic M., Bennett D.C., Dell'Angelica E.C., Raposo G., Marks M.S._x005F_x000D_ Mol. Biol. Cell 18:768-780(2007) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.11"The dystonia-associated protein torsinA modulates synaptic vesicle recycling."_x005F_x000D_ Granata A., Watson R., Collinson L.M., Schiavo G., Warner T.T._x005F_x000D_ J. Biol. Chem. 283:7568-7579(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN VESICLE RECYCLING, INTERACTION WITH TOR1A, SUBCELLULAR LOCATION, PHOSPHORYLATION.

< 0.066 ng/mL