COMP Chemi-Luminescent ELISA Kit (Human)

ELISA Kit

Wet Ice

cartilage oligomeric matrix protein

May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).

NP_000086

Assay Methodology: Quantitative Sandwich ELISA

Chemiluminescent

Sample - 1:2 - 1:4 - 1:8 - 1:16
Serum (n=5) - 87-102% - 93-105% - 78-93% - 78-94%
EDTA Plasma (n=5) - 91-103% - 80-103% - 81-96% - 83-104%
Heparin Plasma (n=5) - 98-105% - 97-105% - 93-101% - 86-101%

Matrix - Recovery range (%) - Average(%)
Serum (n=5) - 84-101 - 93
EDTA Plasma (n=5) - 80-101 - 94
Heparin Plasma (n=5) - 88-99 - 94

Serum, plasma, tissue homogenates and other biological fluids