IFNL2 Chemi-Luminescent ELISA Kit (Human)

ELISA Kit

Wet Ice

interferon lambda 2

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

NP_742150

Assay Methodology: Quantitative Sandwich ELISA

Chemiluminescent

Sample - 1:2 - 1:4 - 1:8 - 1:16
Serum (n=5) - 85-92% - 87-101% - 85-98% - 78-88%
EDTA Plasma (n=5) - 82-98% - 92-104% - 81-92% - 99-105%
Heparin Plasma (n=5) - 88-104% - 89-103% - 81-99% - 83-101%

Matrix - Recovery range (%) - Average(%)
Serum (n=5) - 96-103 - 99
EDTA Plasma (n=5) - 96-104 - 101
Heparin Plasma (n=5) - 79-99 - 90

Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids