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MAVS ELISA Kit (Human)

MAVS ELISA Kit (Human)

ArtNr	OKCD08191
Hersteller	AVIVA Systems Biology
Menge	96 Wells
Kategorie	Neuroscience Neural Lineage Markers Neuroinflammation ELISA ELISA & Immunoassays ELISA Kits Immunoassay Immunostaining
Typ	Elisa-Kit
Applikationen	ELISA
Specific against	Human (Homo sapiens)
Sensitivity	< 0.068ng/mL
ECLASS 10.1	32160605
ECLASS 11.0	32160605
UNSPSC	41116126
Alias	CARD adapter inducing interferon beta;CARD adaptor inducing IFN-beta;CARDIF;IFN-B promoter stimulator 1;interferon beta promoter stimulator protein 1;IPS1;IPS-1;mitochondrial antiviral-signaling protein;putative NF-kappa-B-activating protein 031N;virus-induced signaling adaptor;virus-induced-signaling adapter;VISA.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	ELISA Kit
Manufacturer - Applications	Enzyme-linked Immunosorbent assay-Sandwich
Manufacturer - Category	Root Catalog/Products/ELISA Kits, Root Catalog/Products/Kit
Shipping Temperature	Wet Ice
Gene symbol	MAVS
Gene Fullname	mitochondrial antiviral signaling protein
Reconstitution and storage	2°C to 8°C\|-20°C
Description of target	Required for innate immune defense against viruses. Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.
Nucleotide accession_num	NM_001206491.1
Protein accession_num	NP_001193420.1
Protein name	Mitochondrial antiviral-signaling protein
Kit Components	Component: Amount MAVS Microplate: 96 Wells (12 x 8 Well strips)MAVS Lyophilized Standard: 2100X MAVS HRP-Detector Anitbody: 1 x 120 uL100X Avidin-HRP Conjugate: 1 x 120 uLStandard Diluent: 1 x 20 mLDetector Antibody Diluent: 1 x 12 mLConjugate Diluent: 1 x 12 mL30X Wash Buffer: 1 x 20 mLTMB Substrate: 1 x 9 mLStop Solution: 1 x 6 mL
Kit detection	Colorimetric
Kit duration	3h
Kit principle	The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Virus Induced Signaling Adapter (VISA). Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Virus Induced Signaling Adapter (VISA). Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Virus Induced Signaling Adapter (VISA), biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm +/- 10nm. The concentration of Virus Induced Signaling Adapter (VISA) in the samples is then determined by comparing the O.D. of the samples to the standard curve.
Kit reproducibility	Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Virus Induced Signaling Adapter (VISA) were tested 20 times on one plate, respectively. Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Virus Induced Signaling Adapter (VISA) were tested on 3 different plates, 8 replicates in each plate. CV(%) = SD/meanX100 Intra-Assay: CV<10% Inter-Assay: CV<12%
Sample Type	Tissue homogenates, cell lysates and other biological fluids.

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OKCD08191.pdf

OKCD08191-datasheet.pdf

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Menge: 96 Wells

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