DAPK3 ELISA Kit (Mouse) (OKDD00769)

Wet Ice

448

Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. regulates both type i (caspase-dependent) apoptotic and type ii (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. involved in formation of promyelocytic leukemia protein nuclear body (pml-nb). involved in apoptosis involving pawr which mediates cytoplasmic relocation, in vitro phosphorylates pawr (by similarity). phosphorylates myl12b in non-muscle cells leading to reorganization of actin cytoskeleton such as in regulation of cell polarity and cell migration. positively regulates canonical wnt/beta-catenin signaling through interaction with nlk and tcf7l2, disrupts the nlk-tcf7l2 complex thereby influencing the phosphorylation of tcf7l2 by nlk. phosphorylates stat3 and enhances its transcriptional activity. enhances transcription from ar-responsive promoters in a hormone- and kinase-dependent manner. phosphorylates histone h3 on 'thr-11' at centromeres during mitosis (by similarity). phosphorylates rpl13a on 'ser-77' upon interferon-gamma activation which is causing rpl13a release from the ribosome, rpl13a association with the gait complex and its subsequent involvement in transcript-selective translation inhibition.

Quantitative Sandwich ELISA