RAP1GAP2 ELISA Kit (Rabbit)

ELISA Kit

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RAP1GAP2

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.

XP_002718919

Assay Type: Quantitative Sandwich ELISA

Colorimetric, OD 450 nm

Sample Type - 1:2 Dilution - 1:4 Dilution - 1:8 Dilution - 1:16 Dilution
Serum (n=5) - 89-99% - 91-101% - 86-105% - 88-95%
EDTA Plasma (n=5) - 86-98% - 84-100% - 91-101% - 86-98%
Heparin Plasma (n=5) - 81-98% - 87-100% - 83-100% - 81-91%

Sample Type - Range - Mean
Serum (n=5) - 86-104 - 93
EDTA Plasma (n=5) - 89-102 - 97
Heparin Plasma (n=5) - 86-101 - 94

Serum, Plasma, Cell Cultures, Tissue Homogenates, Other Biological Fluids