Partner proteins |
CCNB1, MARK4, TUBB, CCNB1, CDK1, ENO2, MARK1, MARK4, NR1I3, RXRB, RXRG, TUBB, CDK1, ENO2, FYCO1, MARK4 |
Description of target |
MAP4 is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. |