CLEC7A Peptide - N-terminal region (AAP90201)

26 kDa

CLEC7A

Lyophilized powder

Lectin that functions as pattern receptor specific for beta-1, 3-linked and beta-1, 6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation.