CCL5 Protein

ArtNr	OPCB00005
Hersteller	AVIVA Systems Biology
Menge	5 ug
Kategorie	Oncology Neuroscience Neuroinflammation By Cell Type Carcinoma Hematology Leukemia Lymphoma Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Lyophilized
Specific against	other
Purity	> 97% as determined by SDS-PAGE
Sequence	The protein sequence is: <a href='//www.ncbi.nlm.nih.gov/blast/Blast.cgi?PROGRAM=blastp&CLIENT=web&SERVICE=plain&PAGE=Proteins&CMD=Put&DATABASE=nr&CDD_SEARCH=1&AUTO_FORMAT=Semi-auto&SHOW_OVERVIEW=on&SHOW_LINKOUT=on&GET_SEQUENCE=on&NCBI_GI=on&ALIGNMENTS=50
Citations	1. "RANTES: a versatile and controversial chemokine" Appay V., Rowland-Jones S.L. Trends Immunol 22:83-87 (2001) 2. "Identification of RANTES, MIP-1, and MIP-1[1] as the major HIV-suppressive factors produced by CD8+T cells" Cocchi F., De Vico A.L., Garzino-Demo A., Arya S.K., Gallo R.C., Lusso P. Science 270:1811-1815 (1995) 3. A human T cell-specific molecule is a member of a new gene family Schall T.J., Jongstra J., Dyer B.J., Jorgensen J., Clayberger C., Davis M.M., Krensky A.M. J Immunol 141:1018-1025 (1988) 4. "Engineering the glycosaminoglycan-binding affinity, kinetics and oligomerization behavior of RANTES: a tool for generating chemokine-based glycosaminoglycan antagonists" Brandner B., Rek A., Diedrichs-MÃ¶hring M., Wildner G., Kungl A.J. Protein Eng Des Sel. 22:367-373 (2009)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	SISd,eoCP,SCYA5,RANTES,TCP228,D17S136E,SIS-delta
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Protein
Manufacturer - Category	Root Catalog/Products/Recombinant Proteins
Shipping Temperature	Wet Ice
Molecular Weight	7.851 kDa
Gene symbol	CCL5
Gene Fullname	chemokine (C-C motif) ligand 5
Product format	Lyophilized
Reconstitution and storage	Spin tube prior to resuspending. Recommended at 100ug/mL in sterile water Shipping: Room Temp
Description of target	Regulated on Activation, Normal T cell Expressed and Secreted (RANTES) (CCL5) is a proinflammatory chemokine that induces migration and activation of leukocytes, as well as implication in HIV infection. It binds to cell surface receptors CCR1, CCR3, CCR4, and CCR5. Its biological effects on leukocyte activation and HIV infection displays dependence on concentration and on the binding of cell surface glycosaminoglycans.
Biological activity	EC50 = 0.13nM determined by Migration Assay in cells expressing recombinant CCR5

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