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PTPN22 Recombinant Protein

PTPN22 Recombinant Protein

ArtNr	OPCD00401
Hersteller	AVIVA Systems Biology
Menge	10 ug
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Peptides & Proteins Recombinant Proteins Adenocarcinoma Immunoprecipitation Western Blot ELISA SDS-PAGE
Typ	Proteins Recombinant
Applikationen	WB, SDS-PAGE
Specific against	Human (Homo sapiens)
Host	E.coli
Konjugat/Tag	Unconjugated; HIS
Purity	> 95%
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	hematopoietic cell protein-tyrosine phosphatase 70Z-PEP;Lymphoid phosphatase;lymphoid-specific protein tyrosine phosphatase;LYP;LYP1;LYP2;PEP;PEST-domain phosphatase;protein tyrosine phosphatase,non-receptor type 22 (lymphoid);protein tyrosine phosphatase,non-receptor type 8;PTPN22.5;PTPN22.6;PTPN8;tyrosine-protein phosphatase non-receptor type 22.
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Manufacturer - Type	Protein
Manufacturer - Applications	Positive control\|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis\|Western blot
Manufacturer - Category	Root Catalog/Products/Recombinant Proteins
Manufacturer - Conjugate / Tag	N-terminal His Tag
Molecular Weight	31kDa
Gene symbol	PTPN22
Gene Fullname	protein tyrosine phosphatase non-receptor type 22
Protein size	Recombinant
Product format	Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Reconstitution and storage	2°C to 8°C\|-80°C
Description of target	Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106).
Nucleotide accession_num	NM_001193431.2
Protein accession_num	NP_001180360.1
Protein name	Tyrosine-protein phosphatase non-receptor type 22
Formulation	100mMNaHCO3, 500mMNaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Concentration	200 ug/mL (prior to lyoph)

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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OPCD00401-datasheet.pdf

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Menge: 10 ug

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Lieferung vsl. bis 25.12.2025

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