DYRK1A Recombinant Protein

Protein

Root Catalog/Products/Recombinant Proteins

37kDa

dual specificity tyrosine phosphorylation regulated kinase 1A

Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.

Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity).

NP_001387.2

PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.