ADAM17 Recombinant Protein (Human)

Protein

Dry Ice

Useful tool to study enzyme kinetics, cleave target substrates, screen inhibitors.

ADAM metallopeptidase domain 17

Liquid. In 22.5mM TRIS, pH 7.5, containing 4.5 uM ZnCl2, 0.0045% Brij-35 and 10% glycerol.

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.

NP_000630.1

Purified by multi-step chromatography.