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HDAC2 Recombinant Protein (Human)

HDAC2 Recombinant Protein (Human)

ArtNr	OPED00055
Hersteller	AVIVA Systems Biology
Menge	50 ug
Kategorie	Oncology Neuroscience Neural Lineage Markers Metabolism Regulation of Appetite Molecular Targets for Neuroscience Neural Epigenetics By Cell Type Blastoma Carcinoma Hematology Lymphoma Melanoma Sarcoma Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Apoptosis Senescence Proliferation By Organ Lung Cancer Bladder Cancer
Typ	Proteins Recombinant
Format	Liquid
Specific against	Human (Homo sapiens)
Host	Insect Cells
Dry ice	Yes
Citations	Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity: C.M. Trivedi, et al.; Nat. Med. 13, 324 (2007), Abstract; Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappa B suppression: K. Ito, et al.; J. Exp. Med. 203, 7 (2006), Abstract; Histone deacetylases (HDACs): characterization of the classical HDAC family: A.J. de Ruijter, et al.; Biochem. J. 370, 737 (2003), Abstract; CoREST is an integral component of the CoREST- human histone deacetylase complex: A. You, et al.; PNAS U.S.A. 98, 1454 (2001), Abstract; Regulation of transcription factor YY1 by acetylation and deacetylation: Y.L. Yao, et al.; Mol. Cell Biol. 21, 5979 (2001), Abstract; Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.: Y. Zhang et al.; Genes Dev. 13, 1924 (1999), Abstract; Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex: Y. Zhang, et al.; Cell 89, 357 (1997), Abstract; Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression: C.D. Laherty, et al.; Cell 89, 349 (1997), Abstract; Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3: W.M. Yang, et al.; PNAS U.S.A. 93, 12845 (1996), Abstract;
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	HD2;histone deacetylase 2;KDAC2;RPD3;transcriptional regulator homolog RPD3;YAF1;YY1-associated factor 1.
Versandbedingung	Trockeneis
Lieferbar
Manufacturer - Type	Protein
Manufacturer - Category	Root Catalog/Products/Recombinant Proteins
Shipping Temperature	Dry Ice
Molecular Weight	66 kDa
Gene symbol	HDAC2
Gene Fullname	histone deacetylase 2
Protein size	Recombinant
Product format	Liquid. In 50mM TRIS, pH 8.0, 138 mM NaCl and 10% glycerol.
Reconstitution and storage	Store at -80C
Description of target	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
Nucleotide accession_num	NM_001300981.1
Protein accession_num	NP_001287910.1
Protein name	Histone deacetylase 2
Purification	Partially purified by single-step affinity chromatography and gel filtration.

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Lieferung vsl. bis 25.12.2025

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