MMP14 Recombinant Protein (Human)

Protein

Dry Ice

Useful tool to study enzyme kinetics, cleave target substrates, and screen for inhibitors.

matrix metallopeptidase 14

Liquid. In 50mM TRIS, pH 7.5, containing 5mM calcium chloride, 300mM sodium chloride, 20 uM zinc chloride, 0.5% Brij-35, and 30% glycerol.

Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140).

Partially purified by single-step affinity chromatography and gel filtration.