« Zurück
Startseite /
TNFSF10 Recombinant Protein (Human)

TNFSF10 Recombinant Protein (Human)

ArtNr	OPED00143
Hersteller	AVIVA Systems Biology
Menge	100 ug
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis By Cell Type Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis
Typ	Proteins Recombinant
Format	Liquid
Specific against	Human (Homo sapiens)
Host	E.coli
Purity	>95% (SDS-PAGE)
Dry ice	Yes
Citations	Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology: K. Tatzel, et al.; Sci. Rep. 6, 22661 (2016), Application(s): Western blot, Abstract; GDP-mannose-4,6-dehydratase (GMDS) Deficiency Renders Colon Cancer Cells Resistant to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Receptor- and CD95-mediated Apoptosis by Inhibiting Complex II Formation: K. Moriwaki, et al.; J. Biol. Chem. 286, 43123 (2011), Application(s): Death induction and sub-G1 assays of GDP-mannose-4,6-dehydratase-rescued HCT116 cells, Abstract; Full Text Bortezomib Overcomes Tumor Necrosis Factor-related Apoptosis-inducing Ligand Resistance in Hepatocellular Carcinoma Cells in Part through the Inhibition of the Phosphatidylinositol 3-Kinase/Akt Pathway: K.F. Chen, et al.; J. Biol. Chem. 284, 11121 (2009), Application(s): Death induction of sensitized Huh-7, Sk-hep1, Hep3B and HCC cells, Abstract; Full Text Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death: T. Panaretakis, et al.; EMBO J. 28, 578 (2009), Abstract; Treating Metastatic Solid Tumors With Bortezomib and a Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor Agonist Antibody: A. Shanker, et al.; J. Natl. Cancer Inst. 100, 649 (2008), Application(s): Death induction of sensitized ACHN, A498, MDA-MB-231 and BT-549 cells, Abstract; Full Text A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through 15-deoxy-dell 12, 14 prostaglandin J2 production: H. Hasegawa, et al.; Blood 110, 1664 (2007), Application(s): Death induction of sensitized KOB, KK1, ST1, SO4, HL60, HS-sultan, Ramos, K562, MOLT-4, ATLL and primary ATLL cells, Abstract; Full Text Association of the Astrovirus Structural Protein VP90 with Membranes Plays a Role in Virus Morphogenesis: E. MÃ©ndez, et al.; J. Virol. 81, 10649 (2007), Application(s): Death induction of astrovirus-infected Caco-2 cells, Abstract; Full Text The Farnesyltransferase Inhibitor Lonafarnib Induces CCAAT/Enhancer-binding Protein Homologous Protein-dependent Expression of Death Receptor 5, Leading to Induction of Apoptosis in Human Cancer Cells: S.Y. Sun, et al.; J. Biol. Chem. 282, 18800 (2007), Application(s): Death induction of H1792, H460 and H157 cells, Abstract; Full Text Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells: H. Hasegawa, et al.; Blood 107, 679 (2006), Application(s): Death induction of sensitized PBMCs, KOB, ST1, Jurkat, U937, K562, HL60 andRamos cells, Abstract; Full Text Nonsecreted Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) Can Induce Apoptosis in Human Prostate Cancer Cells by IGF-independent Mechanisms without Being Concentrated in the Nucleus: N. Bhattacharyya, et al.; J. Biol. Chem. 281, 24588 (2006), Application(s): Death induction of PC-3 cells, Abstract; Full Text Sensitization of TRAIL-resistant cells by inhibition of heat shock protein 90 with low-dose geldanamycin: Y. Ma, et al.; Mol. Cancer Ther. 5, 170 (2006), Application(s): Death induction of sensitized LNCaP and DU145 cells, Abstract; Full Text The role of NF-kappa B-1 and NF-kappa B-2-mediated resistance to apoptosis in lymphomas: L. Bernal-Mizrachi, et al.; PNAS 103, 9220 (2006), Application(s): Death induction of 204-3-1, NK-H and NK-92 cells and analysis of resistance to TRAIL-induced cell death of Daudi, SC, F8 and BLA cells, Abstract; Full Text Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes: F. Rubio-Moscardo, et al.; Blood 106, 3214 (2005), Application(s): Death induction of VAL and TRAIL-R1/-R2 restored SU-DHL6 and Namalwa cells, Abstract; Full Text Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy: C. Gajate & F. Mollinedo; J. Biol. Chem. 280, 11641 (2005), Abstract; Full Text Human Retinoblastoma Cells Are Resistant to Apoptosis Induced by Death Receptors: Role of Caspase-8 Gene Silencing: V. Poulaki, et al.; Invest. Ophthalmol. Vis. Sci. 46, 358 (2005), Application(s): Death induction of sensitized Y79, WERI-Rb1 and SK-N-MC cells, Abstract; Full Text X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells: A. Amantana, et al.; Mol. Cancer Ther. 3, 699 (2004), Application(s): Death induction of sensitized DU145 cells, Abstract; Full Text A Novel Single Amino Acid Deletion Caspase-8 Mutant in Cancer Cells That Lost Proapoptotic Activity: B. Liu, et al.; J. Biol. Chem. 277, 30159 (2002), Application(s): Death induction of MCF7, MDA468, DiFi, HN5, and H460 cells and analysis of resistance to TRAIL-induced cell death of A431 cells, Abstract; Full Text An Inducible Pathway for Degradation of FLIP Protein Sensitizes Tumor Cells to TRAIL-induced Apoptosis: Y. Kim, et al.; J. Biol. Chem. 277, 22320 (2002), Application(s): Death induction of sensitized PPC-1, PC3, OVCAR-3, SK-OV-3, HT29, COLO205, LNCaP, HeLa, HEY3, and HT1080 cells, Abstract; Full Text Mifepristone Pretreatment Overcomes Resistance of Prostate Cancer Cells to Tumor Necrosis Factor {alpha }-related Apoptosis-inducing Ligand (TRAIL): M.A. Eid, et al.; Mol. Cancer Ther. 1, 831 (2002), Application(s): Death induction of sensitized LNCaP and LNCaP C4-2 cells, Abstract; Full Text Regulation of leukemic cell adhesion, proliferation, and survival by beta -catenin: E.J. Chung, et al.; Blood 100, 982 (2002), Application(s): Death induction of Jurkat cells, Abstract; Full Text NF-kappa B signals induce the expression of c-FLIP: O. Micheau, et al.; Mol. Cell. Biol. 21, 5299 (2001), Abstract; Full Text Roles of TNF-Related Apoptosis-Inducing Ligand in Experimental Autoimmune Encephalomyelitis: B. Hilliard, et al.; J. Immunol. 15, 166 (2001), Application(s): Death induction of Jurkat and K562 cells, Abstract; Full Text The cytokines tumor necrosis factor alpha (TNF-alpha ) and TNF-related apoptosis-inducing ligand differentially modulate proliferation and apoptotic pathways in human keratinocytes expressing the h: J.R. Basile, et al.; J. Biol. Chem. 276, 22522 (2001), Abstract; Full Text Tumor necrosis factor (TNF) and phorbol ester induce TNF-related apoptosis-inducing ligand (TRAIL) under critical involvement of NF-kappa B essential modulator (NEMO)/IKKgamma: D. Siegmund, et al.; J. Biol. Chem. 276, 43708 (2001), Abstract; Full Text Augmentation of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis by the Synthetic Retinoid 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene Carboxylic Acid (CD437) through Up-Regulation of TRAIL Receptors in Human Lung Cancer Cells: S.Y. Sun, et al.; Cancer Res. 60, 7149 (2000), Application(s): Death induction of sensitized H460, A549, H1944, H1792, H157, H596, NHBE and SAE cells, Abstract; Full Text Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy: A.M. Chinnaiyan, et al.; PNAS 97, 1754 (2000), Abstract; FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2: M.R. Sprick, et al.; Immunity 12, 599 (2000), Abstract; Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule: N. Holler, et al.; Nat. Immunol. 1, 489 (2000), Abstract; The death domain kinase RIP is essential for TRAIL (Apo2L)-induced activation of Ikappa B kinase and c-Jun N-terminal kinase: Y. Lin et al.; Mol. Cell Biol. 20, 6638 (2000), Abstract; Thyroid carcinoma cells are resistant to FAS-mediated apoptosis but sensitive to tumor necrosis factor-related apoptosis-inducing ligand: N.S. Mitsaides et al.; Cancer Res. 60, 4122 (2000), Abstract; Full Text Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity: P. Schneider, et al.; J. Exp. Med. 187, 1205 (1998), Abstract; Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells: T.S. Griffith, et al.; J. Immunol. 161, 2833 (1998), Abstract; An antagonist decoy receptor and a death domain-containing receptor for TRAIL: G. Pan, et al.; Science 277, 815 (1997), Abstract; Characterization of two receptors for TRAIL: P. Schneider, et al.; FEBS Lett. 416, 329 (1997), Abstract; Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors: J.P. Sheridan, et al.; Science 277, 818 (1997), Abstract; Inhibition of death receptor signals by cellular FLIP: M. Irmler, et al.; Nature 388, 190 (1997), Abstract; Interleukin 1 beta -converting enzyme related proteases/caspases are involved in TRAIL-induced apoptosis of myeloma and leukemia cells: S.M. Mariani et al.; J. Cell. Biol. 137, 221 (1997), Abstract; The receptor for the cytotoxic ligand TRAIL: G. Pan, et al.; Science 276, 111 (1997), Abstract; Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors: M. Thome, et al.; Nature 386, 517 (1997), Abstract; Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family: R.M. Pitti, et al.; J. Biol. Chem. 271, 12687 (1996), Abstract; Identification and characterization of a new member of the TNF family that induces apoptosis: S.R. Wiley, et al.; Immunity 3, 673 (1995), Abstract;
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Apo-2 ligand;Apo-2L;APO2L;CD253;chemokine tumor necrosis factor ligand superfamily member 10;TL2;TNF-related apoptosis inducing ligand TRAIL;TNF-related apoptosis-inducing ligand;TNLG6A;TRAIL;tumor necrosis factor (ligand) family,member 10;tumor necrosis factor (ligand) superfamily,member 10;tumor necrosis factor apoptosis-inducing ligand splice variant delta;tumor necrosis factor ligand 6A;tumor necrosis factor ligand superfamily member 10;tumor necrosis factor superfamily member 10.
Versandbedingung	Trockeneis
Lieferbar
Manufacturer - Type	Protein
Manufacturer - Category	Root Catalog/Products/Recombinant Proteins
Shipping Temperature	Dry Ice
Molecular Weight	20 kDa
Gene symbol	TNFSF10
Gene Fullname	TNF superfamily member 10
Protein size	Recombinant
Product format	Liquid. In 10mM Na2HPO4, 2mM KH2PO4, 2.7mM KCl, 500mM NaCl, 10% glycerol, 0.1mM DTT.
Reconstitution and storage	Store at -80C
Description of target	Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Nucleotide accession_num	NM_001305624.1
Protein accession_num	NP_001292553.1
Protein name	Tumor necrosis factor ligand superfamily member 10
Purification	Purified by multi-step chromatography.

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

OPED00143-datasheet.pdf

Sicherheitsdatenblatt anfordern

Einfache Bestellung Periodische Bestellung

Menge: 100 ug

lieferbar

Lieferung vsl. bis 25.12.2025

Express-Lieferung: 2 Tage sparen

Vergleichen

Auf den Wunschzettel

Angebot anfordern