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TNFRSF10B Recombinant Protein (Human)

TNFRSF10B Recombinant Protein (Human)

ArtNr	OPED00145
Hersteller	AVIVA Systems Biology
Menge	50 ug
Kategorie	Oncology By Cell Type Carcinoma Hematology Myeloma Peptides & Proteins Recombinant Proteins Cell Biology Cell Status Apoptosis ELISA Immunostaining
Typ	Proteins Recombinant
Format	Lyophilized
Applikationen	ELISA
Specific against	Human (Homo sapiens)
Host	HEK293 cells
Purity	>95% (SDS-PAGE)
Citations	Serine 574 phosphorylation alters transcriptional programming of FOXO3 by selectively enhancing apoptotic gene expression: Z. Li, et al.; Cell Death Differ. 23, 583 (2016), Abstract; Death receptor 5 signaling promotes hepatocyte lipoapoptosis: S.C. Cazanave, et al.; J. Biol. Chem. 286, 39336 (2011), Abstract; Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8: M.A. Laussmann, et al.; Cell Death Differ. 18, 1584 (2011), Abstract; Two adjacent trimeric fas ligands are required for fas signaling and formation of a death-inducing signaling complex: N. Holler, et al.; Mol. Cell. Biol. 23, 1428 (2003), Abstract; Full Text Death ligand TRAIL induces no apoptosis but inhibits activation of human (auto)antigen-specific T cells: J.D. Lunemann, et al.; J. Immunol. 168, 4881 (2002), Abstract; Full Text Induction of TRAIL-mediated glioma cell death by human T cells: J. DÃ¶rr, et al.; J. Neuroimmunol. 122, 117 (2002), Abstract; Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha (1)beta (2), Fas ligand, and TNF-related apoptosis-inducing ligand: G. Lu, et al.; J. Immunol. 168, 1831 (2002), Abstract; Full Text Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling in Activated T Cells Abrogates TRAIL-Induced Apoptosis Upstream of the Mitochondrial Amplification Loop and Caspase-8: T.S. Soderstrom, et al.; J. Immunol. 169, 2851 (2002), Abstract; T cells require TRAIL for optimal graft-versus-tumor activity: C. Schmaltz, et al.; Nat. Med. 8, 1433 (2002), Abstract; TRAIL/Apo-2 ligand induces primary plasma cell apoptosis: J. Ursini-Siegel, et al.; J. Immunol. 169, 5505 (2002), Abstract; Full Text Development of improved soluble inhibitors of FasL and CD40L based on oligomerized receptors: N. Holler, et al.; J. Immunol. Methods 237, 159 (2000), Abstract; The tumor necrosis factor-related apoptosis-inducing ligand receptors TRAIL-R1 and TRAIL-R2 have distinct cross-linking requirements for initiation of apoptosis and are non-redundant in JNK activation: F. MÃ¼hlenbeck, et al.; J. Biol. Chem. 275, 32208 (2000), Abstract; Full Text
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	apoptosis inducing protein TRICK2A/2B;apoptosis inducing receptor TRAIL-R2;CD262;cytotoxic TRAIL receptor-2;death domain containing receptor for TRAIL/Apo-2L;death receptor 5;DR5;Fas-like protein;KILLER;KILLER/DR5;p53-regulated DNA damage-inducible cell death receptor(killer);TNF-related apoptosis-inducing ligand receptor 2;TRAILR2;TRAIL-R2;TRICK2;TRICK2A;TRICK2B;TRICKB;tumor necrosis factor receptor superfamily member 10B;tumor necrosis factor receptor superfamily,member 10b;tumor necrosis factor receptor-like protein ZTNFR9;ZTNFR9.
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Protein
Manufacturer - Category	Root Catalog/Products/Recombinant Proteins
Shipping Temperature	Wet Ice
Molecular Weight	58 kDa
Manufacturer - Application Additional Information	ELISA: binds to TRAIL at 10-100 ng/ml.
Gene symbol	TNFRSF10B
Gene Fullname	TNF receptor superfamily member 10b
Protein size	Recombinant
Product format	Lyophilized. Contains PBS.
Reconstitution and storage	Reconstitute with 50 ul sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein. Store at -20C
Description of target	Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Protein name	Tumor necrosis factor receptor superfamily member 10B

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