MET Protein

Protein

Wet Ice

MET

Liquid 50mM Tris, 300mM NaCl, 10% glycerol (pH 7.5)
Physical Appearance: Sterile filtered clear colorless solution

Mesenchymal epithelial transition factor (c-MET) is a proto-oncogenic receptor tyrosine kinase. The endogenous ligand for c-MET is HGF (hepatocyte growth factor), which is a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells. In the adult, c-MET protein expression is limited to stem and progenitor cells and is required for wound healing and hepatocyte regeneration. In the embryo, c-MET receptors are expressed on cells of epithelial origin, which are vital for invasive growth and mediate epithelial-mesenchymal transition (EMT). Abnormal activation of the HGF/MET pathway leads to a variety of cancers. c-MET mutation is linked with a poor prognosis since it can trigger tumor growth, angiogenesis and metastasis.
Product Description: Met Proto-Oncogene Human Recombinant produced in Insect cells amino acids 1039-1345.

1 mg/ml