Uricase Protein

Protein

Room Temperature

URICASE

Lyophilized 5mg sucrose, 25mg glycine, 0.1mg Tween-80, 13.6 mg Na₂HPO₄*2H₂0 and 0.33 mg NaH2PO4*2H20.

Urate oxidase catalyzes the enzymatic oxidation (degrades) of uric acid into allantoin, an inactive and soluble metabolite, which is 5 to 10 fold more soluble than uric acid. Urate oxidase is an enzyme of the purine breakdown pathway that catalyses the oxidation of uric acid to allantoin. Uricase is present in numerous diverse organisms, but not in higher primates including human. Hyperuricaemia is most commonly associated with gout and also occurs in mammalians with malignancy, especially those with lymphoid malignancies due to rapid cell turnover and an increased rate of purine metabolism. Uricase is effective in the prevention and treatment of hyperuricaemia in mammalians with malignancy and in those who have undergone transplantation. It appears to act rapidly, safely and induces a more dramatic decrease in plasma levels of uric acid. The cDNA coding for urate-oxidase was cloned from a strain of Aspergillus flavus. The monomer protein has no intra- or inter-disulfide bridges.

Uricase