Tissue factor Protein (OPPA01228)

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Hersteller AVIVA Systems Biology
Kategorie
Typ Proteins
Specific against other
Format Tissue factor protein is supplied in 22mM Tris.HCl pH8.0, 1mM EDTA and 50% glycerol. Physical appearance: Sterile Filtered clear solution.
Menge 2ug
Host E.coli
ArtNr OPPA01228
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Gene symbol
Tissue Factor
Protein name
Tissue factor
Product format
Liquid.
Tissue factor protein is supplied in 22mM Tris.HCl pH8.0, 1mM EDTA and 50% glycerol. Physical appearance: Sterile Filtered clear solution.
Gene id
2152
Reconstitution and storage
Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. Please avoid freeze thaw cycles.
Description of target
Tissue factor is well-known as the main cellular initiator of blood coagulation. The Tissue factor gene encodes coagulation factor III which is a cell surface glycoprotein that enables cells to initiate the blood coagulation cascades, and functions as the high-affinity receptor for the coagulation factor VII. Following vessel injury, the Tissue Factor and Factor VIIa complex activates the coagulation protease cascade, which leads to fibrin deposition and activation of platelets. The ensuing complex presents a catalytic event, which is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Therefore, Tissue factor has a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. Tissue Factor can also be stimulated by the inflammatory mediators interleukin 1 and TNF, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response.
Tissue factor is the only one in the coagulation pathway for which a congenital deficiency has not been described. Certain levels of Tissue Factor are essential for the maintained viability and growth of endothelium and Tissue Factor-expressing tumor cells. Additionally, abnormal Tissue Factor expression inside the vasculature initiates life threatening thrombosis in various diseases, for example sepsis, atherosclerosis, and cancer. Alternative spliced Tissue Factor expression advances tumor growth, and is linked to increased tumor cell proliferation and angiogenesis in pancreatic cancer.
Purification
The Tissue factor is purified by proprietary chromatographic techniques.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Drywet
Wet Ice

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Menge: 2ug
Lieferbar: In stock
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