BIRC7 Protein

Protein

N-terminal His Tag

34 kDa

BIRC7

Liquidcontaining 20mM Tris (pH 8), 1mM DTT, 0.1M NaCl, 2mM EDTA and 20% glycerol
Physical Appearance: Sterile filtered colorless solution

BIRC7 is a part of the inhibitor of apoptosis protein (IAP) family and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is necessary for inhibitory activity & cooperates with caspases, while the RING finger domain sometimes increases anti-apoptotic activity but doesn't inhibit apoptosis by itself. 2 transcript variants encoding diverse isoforms have been found for this gene. The 2 isoforms have dissimilar antiapoptotic characteristics, with isoform a protecting cells from apoptosis induced by staurosporine and isoform b defending cells from apoptosis. BIRC7 has direct contact with several caspases together with caspase-3, caspase-7, & caspase –9. BIRC7 inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c, and dATP.

Baculoviral IAP repeat-containing protein 7

1 mg/ml