SMAD2 Protein

ArtNr	OPPA01845
Hersteller	AVIVA Systems Biology
Menge	2 ug
Kategorie	Oncology Neuroscience Neural Lineage Markers Targets for Rodent Neurosciences By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins Adenocarcinoma By Organ Colorectal Cancer Neurodegeneration Markers
Typ	Proteins Recombinant
Format	Liquid
Specific against	Human (Homo sapiens)
Host	E.coli
Konjugat/Tag	HIS
Purity	Greater than 95.0% as determined by SDS-PAGE.
Sequence	MGSSHHHHHH SSGLVPRGSH MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK KLKKTGRLDE LEKAITTQNC NTKCVTIPSTCSEIWGLSTP NTIDQWDTTG LYSFSEQTRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELKAIENCE YAFNLKKDEV CVNPYHYQRV ETPVLPPVLVPRHTEILTEL PPLDDYTHSI PENTNFPAGI EPQS
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	JV18,MADH2,MADR2,JV18-1,hMAD-2,hSMAD2
Similar products	SMAD2
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Type	Protein
Manufacturer - Category	Root Catalog/Products/Recombinant Proteins
Manufacturer - Conjugate / Tag	N-terminal His Tag
Shipping Temperature	Wet Ice
Molecular Weight	54 kDa
Gene symbol	SMAD2
Protein size	Recombinant
Product format	Liquid 20mM Tris-HCl (pH 8) and 100mM NaCl
Reconstitution and storage	Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen, at -20°C for longer periods of time. For long-term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze/thaw cycles.
Description of target	SMAD2 is part of the SMAD family of proteins that mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. Phosphorylated SMAD2 is then able to form a complex with SMAD4 or SARA. These complexes accumulate in the cell nucleus, where they are directly participating in the regulation of gene expression. SMAD2 mediates the signal of the TGF-beta, and therefore regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. TGF-beta 1 acts on adjacent stromal cells to turn on SMAD2 signalling that could lead to stromal decidualization. SMAD2 is the downstream signal transducers of TGF-beta-1 in human dental pulp cells.
Protein accession_num	NP_001003652.1
Protein name	Mothers against decapentaplegic homolog 2
Concentration	Varies by lot. See vial for concentration.

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