GADD45B Protein (OPPA02011)

Hersteller AVIVA Systems Biology
Kategorie
Typ Proteins
Specific against other
Format The GADD45B protein solution contains 20mM Tris-HCl pH-7.5 and 20% glycerol. Physical appearance: Sterile Filtered colorless solution.
Menge 10ug
Host E.coli
ArtNr OPPA02011
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Gene symbol
GADD45B
Protein name
Growth arrest and DNA damage-inducible protein GADD45 beta
Product format
The GADD45B protein solution (1 mg/ml) contains 20mM Tris-HCl pH-7.5 and 20% glycerol. Physical appearance: Sterile Filtered colorless solution.
Gene id
4616
Reconstitution and storage
Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Description of target
GADD45B is part of the nuclear proteins to interact with various proteins whose transcript levels are raised after stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45B reacts to environmental stresses by mediating activation of the p38/JNK pathway which is mediated through their protein binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. GADD45B is involved in the regulation of growth and apoptosis. GADD45b takes part during chondrocyte terminal differentiation and mediates MMP-13 gene expression. GADD45 in B cells is induced by CD40 via a mechanism that involves NF-kappa B and that induction suppresses Fas-mediated killing. GADD45b is down-regulated in most cases of hepatocellular carcinoma (HCC), and is a molecular marker in the diagnosis of HCC and as a possible therapeutic target.
Purity
Greater than 95.0% as determined by SDS-PAGE.
Drywet
Wet Ice

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Menge: 10ug
Lieferbar: In stock
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