IL-33 Protein (OPPB00175)

Human IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family. It binds and signals through the IL-1RL1/ST2 receptor activating NF-kappaB and MAP kinases. IL-33 induces production of TH2 cell related cytokines, including IL-4, IL-5 and IL-13, and exerts multiple inflammation related bioactivities. Recombinant human IL-33 is a 17.9 kDa protein containing 159 amino acid residues.

Preparation: The ED50 was determined by the dose - dependent stimulation of the proliferation of murine D10S cells is <= 0.05 ng/ml, corresponding to a specific activity of >= 2 x 107units/mg.Storage: The lyophilized IL-33 recombinant protein is stable for at least 2 years from date of receipt at -20C. Reconstituted IL-33 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20C. As with any protein, exposing IL-33 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.