sTNF RII / TNFRSF1B ELISA Kit, Human

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human sTNF RII. The Human sTNF RII/TNFRSF1B is for research use only. Not for diagnostic or therapeutic procedures. Tumor necrosis factor receptor II (TNFRII), also known as tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), is a membrane receptor that binds tumor necrosis factor-alpha (TNF-alpha). This protein and TNF-receptor I form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2 (TRAF2), which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.

Sandwich ELISA

serum, plasma, cell culture supernates

4C (unopened)
standard stored at -20C, others stored at 4C (opened)

0.08 pg/ml

103 % - 118 %

2.6 - 4.9 ng/ml

2.4 % - 5.4 %