Proprotein Convertase 9 / PCSK9 ELISA Kit, Human

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human PCSK9. The Human Proprotein Convertase 9/PCSK9 is for research use only. Not for diagnostic or therapeutic procedures. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an enzyme belonging to the proteinase K subfamily of the secretory subtilase family. It is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. PCSK9 binds to the receptor for low-density lipoprotein (LDL) cholesterol, inducing LDLR degradation. Variants of PCSK9 can reduce or increase circulating cholesterol. Other variants are associated with a rare autosomal dominant familial hypercholesterolemia (HCHOLA3). The mutations increase its protease activity, reducing LDLR levels and preventing the uptake of cholesterol into the cells.

Sandwich ELISA

serum, plasma, cell culture supernates

4C (unopened)
standard stored at -20C, others stored at 4C (opened)

3.39 pg/ml

77.7 - 249.0 ng/ml

1.7 % - 7.6 %