IL-1ra / IL-1F3 ELISA Kit, Human

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human IL-1ra. The Human IL-1ra/IL-1F3 ELISA is for research use only. Not for diagnostic or therapeutic procedures. Interleukin-1 receptor antagonist (IL-1ra) encoded by the IL1RN gene is a member of the interleukin 1 cytokine family. IL-1ra is secreted by various types of cells including immune cells, epithelial cells, and adipocytes, and is a natural inhibitor of the pro-inflammatory effect of IL-1beta. This protein inhibits the activities of IL-1alpha and IL-1beta, and modulates a variety of IL-1 related immune and inflammatory responses. Mutations in the IL1RN gene results in a rare disease called deficiency of the interleukin-1–receptor antagonist (DIRA). Variants of the IL1RN gene is also associated with risk of schizophrenia. Elevated levels of IL1RN has been found in serum of schizophrenia patients. IL-1ra is used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role.

Sandwich ELISA

serum, plasma, cell culture supernates

4C (unopened)
standard stored at -20C, others stored at 4C (opened)

7.71 pg/ml

87 % - 108 %

23.7 - 2153.8 pg/ml

2.5 % - 3.8 %