Serpin E1 / PAI-1 ELISA Kit, Human

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human PAI-1. The Human Serpin E1/PAI-1 ELISA is for research use only. Not for diagnostic or therapeutic procedures. Serpin E1, also known as plasminogen activator inhibitor-1 (PAI-1), is mainly produced by the endothelium (cells lining blood vessels), but is also secreted by other tissue types, such as adipose tissue. It is a serine protease inhibitor (serpin) that functions as the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and hence fibrinolysis. PAI-1 is present in increased levels in various disease states (such as a number of forms of cancer), as well as in obesity and the metabolic syndrome. It has been linked to the increased occurrence of thrombosis in patients with these conditions.

Sandwich ELISA

serum, plasma, cell culture supernates

4C (unopened)
standard stored at -20C, others stored at 4C (opened)

1.53 pg/ml

80 % - 118 %

4.8 - 20.3 ng/ml

2.3 % - 4.8 %