Human Bcl-2 ELISA Kit

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human Bcl-2. The Human Bcl-2 ELISA is for research use only. Not for diagnostic or therapeutic procedures. B-cell lymphoma 2 (Bcl-2), is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inducing (pro-apoptotic) or inhibiting (anti-apoptotic) apoptosis. Bcl-2 is specifically considered an important anti-apoptotic protein and is thus classified as an oncogene. Bcl-2 is known to regulate mitochondrial dynamics, and is involved in the regulation of mitochondrial fusion and fission. Additionally, in pancreatic beta-cells, Bcl-2 and Bcl-XL are known to be involved in controlling metabolic activity and insulin secretion. Damage to the Bcl-2 gene has been identified as a cause of a number of cancers, including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung cancer, and a possible cause of schizophrenia and autoimmunity. It is also a cause of resistance to cancer treatments.

Sandwich ELISA

serum, plasma, cell culture supernates

4C (unopened)
standard stored at -20C, others stored at 4C (opened)

50.25 pg/ml

90% - 110%

493.9-65986.3 pg/ml

4.0% - 4.9%