Human sVCAM-1/CD106 ELISA Kit

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of human sVCAM-1. The Human sVCAM-1 ELISA is for research use only. Not for diagnostic or therapeutic procedures. Vascular cell adhesion molecule 1 (VCAM-1), also known as CD106), is a 100-110 kDa, type I transmembrane glycoprotein typically characterized by the presence of seven C2-type immunoglobulin (Ig) domains and functions as a cell adhesion molecule. The VCAM-1 protein mediates the adhesion of lymphocytes, monocytes, eosinophils, and basophils to vascular endothelium. VCAM-1 is an endothelial ligand for VLA-4 (Very Late Antigen-4 or alpha4beta1) of the beta1 subfamily of integrins, and for integrin alpha4beta7. VCAM-1 expression has also been observed in other cell types. It has also been shown to interact with EZR and Moesin. Other roles proposed for VCAM-1 include the regulation of osteoclastogenesis via a cell-to-cell contact mechanism and the induction of sickle cell adherence to vascular endothelial cells during hypoxemia. It also functions in leukocyte-endothelial cell signal transduction. Monitoring of sVCAM-1 levels in serum provides more detailed insights in several pathological situations such as atherosclerosis and rheumatoid arthritis.

Sandwich ELISA

serum, plasma, cell culture supernates

4C (unopened)
standard stored at -20C, others stored at 4C (opened)

2.65 pg/ml

99 % - 111 %

176506.8 - 428677.1 pg/ml

4.4 % - 7.0 %