Human MMP-2 ELISA Kit

Three samples were tested on one plate

3-4h

Matrix metalloproteinase-2 (MMP-2) also known as 72 kDa type IV collagenase and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene. Activation of MMP-2 requires proteolytic processing. MMP-2 is involved in many events, such as cancer progression, cancer cell invasion, cell signaling, neovascularization and lymphangiogenesis. Mutations in the MMP2 gene are associated with Torg-Winchester syndrome, multicentric osteolysis, arthritis syndrome, and possibly keloids.

Online product mannual

solid

0.02% sodium azide

This assay employs the quantitative sandwich enzyme immunoassay technique for the quantitative detection of rat VEGF. The Rat VEGF ELISA is for research use only. Not for diagnostic or therapeutic procedures.
Vascular endothelial growth factor (VEGF) is a sub-family of growth factors, to be specific, the platelet-derived growth factor family of cystine-knot growth factors. They are important signaling proteins involved in both vasculogenesis (the denovoformation of the embryonic circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature).VEGF is a signal protein produced by cells that imulates vasculogenesis and angiogenesis. It is part of the system that restores the oxygen supply to tissues when blood circulation is inadequate. VEGF is best known for its role in vasculogenesis. During embryogenesis, VEGF regulates the proliferation, migration, and survival of endothelial cells, thus regulating blood vessel density and size, but playing no role in determining vascular patterns.
Serum concentration of VEGF is high in bronchial asthma and diabetes mellitus. When VEGF is overexpressed, it can contribute to disease. Solid cancers cannot grow beyond a limited size without an adequate blood supply; cancers that can express VEGF are able to grow and metastasize. Overexpression of VEGF can cause vascular disease in the retina of the eye and other parts of the body. Drugs such as bevacizumab and Ranibizumab can inhibit VEGF and control or slow those diseases.

Online product mannual

Online product mannual

100µL

Colorimetric