Anti-Human CD8a APC

ArtNr	10121-80-25
Hersteller	BioGems
Menge	25 tests
Kategorie	Metabolism Glucose Homeostasis Antibodies Flow Cytometry Primary Antibodies
Typ	Antibody
Format	APC
Applikationen	FC
Clon	OKT8
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a
Konjugat/Tag	APC
Citations	Sayos, J., Wu, C., Morra, M., Wang, N., Zhang, X., Allen, D., ... & Terhorst, C. (1998). The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature, 395(6701), 462-469. Thomas, Y., Sosman, J., Irigoyen, O., Friedman, S. M., Kung, P. C., Goldstein, G., & Chess, L. (1980). Functional analysis of human T cell subsets defined by monoclonal antibodies. I. Collaborative TT interactions in the immunoregulation of B cell differentiation. The Journal of Immunology, 125(6), 2402-2408. Campanelli, R., Palermo, B., Garbelli, S., Mantovani, S., Lucchi, P., Necker, A., ... & Giachino, C. (2002). Human CD8 co-"receptor is strictly involved in MHC-"peptide tetramer-"TCR binding and T cell activation. International immunology, 14(1), 39-44.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Lieferbar
Description	The OKT8 monoclonal antibody specifically reacts with human CD8α molecule, a type I transmembrane glycoprotein of 32-34 kDa. CD8α is a member of the Ig superfamily, expressed as a homodimer (CD8αα) or as a heterodimer (CD8αβ). CD8+ αβ T lymphocytes express both CD8αα and CD8αβ, while some T lymphocytes and the natural killer cells express only the homodimers. CD8 binds to MHC class I and influences the development and the activation of T lymphocytes. OKT8, RPA-T8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitope or block each other by steric hindrance.
Storage Temperature	4C
Formulation	Phosphate-buffered aqueous solution, ≤ 0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Preperation	The product should be stored undiluted at 4C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Interest	Adaptive Immunity

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10121-80-25-datasheet.pdf

10121-80-25-safety-datasheet.pdf