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Anti-Human CD152 (CTLA-4) APC

Anti-Human CD152 (CTLA-4) APC

ArtNr	14611-80-25
Hersteller	BioGems
Menge	25 tests
Kategorie	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Carcinoma Flow Cytometry Primary Antibodies
Typ	Antibody
Format	APC
Applikationen	FC
Clon	BNI3
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
Konjugat/Tag	APC
Citations	Barclay, A. N., Brown, M. H., Law, S. A. K. A., McKnight, A. J., Tomlinson, M. G., & van der Merwe, P. A. (1997). The leucocyte antigen factsbook. Academic Press. Lindsten, T., Lee, K. P., Harris, E. S., Petryniak, B., Craighead, N., Reynolds, P. J., ... & Gray, G. S. (1993). Characterization of CTLA-4 structure and expression on human T cells. The Journal of Immunology, 151(7), 3489-3499. Kuiper, H. M., Brouwer, M., Linsley, P. S., & Van Lier, R. A. (1995). Activated T cells can induce high levels of CTLA-4 expression on B cells. The Journal of Immunology, 155(4), 1776-1783.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Lieferbar
Description	The BNI3 monoclonal antibody specifically reacts with human CD152, the Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4). CTLA-4 is expressed on activated CD28+ T cells, and binds the B7 family members B7-1 (CD80) and B7-2 (CD86). The structure of CTLA-4 is similar to the structure of CD28, but the two molecules seem to have opposite roles on the T lymphocytes. CTLA-4 inhibits the progression of T cell activation, while CD28 stimulates it. This result explains the stimulating role that the immobilization of BNI3 plays on the T lymphocytes proliferation induced by CD28.
Storage Temperature	4C
Formulation	Phosphate-buffered aqueous solution, ph7.2.
Preperation	The product should be stored undiluted at 4C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µ g of the protein.
Research Interest	Adaptive Immunity

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14611-80-25-datasheet.pdf

14611-80-25-safety-datasheet.pdf