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Anti-Human CD253 (TRAIL) SAFIRE Purified

Anti-Human CD253 (TRAIL) SAFIRE Purified

ArtNr	25611-25-100
Hersteller	BioGems
Menge	100 ug
Kategorie	Neuroscience Aging & Neurological Disorders Antibodies Flow Cytometry Primary Antibodies
Typ	Antibody
Format	SAFIRE (Functional)
Applikationen	FC
Clon	RIK-2
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Citations	Kayagaki, N., Yamaguchi, N., Nakayama, M., Kawasaki, A., Akiba, H., Okumura, K., & Yagita, H. (1999). Involvement of TNF-related apoptosis-inducing ligand in human CD4+ T cell-mediated cytotoxicity. The Journal of Immunology, 162(5), 2639-2647. Pitti, R. M., Marsters, S. A., Ruppert, S., Donahue, C. J., Moore, A., & Ashkenazi, A. (1996). Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. Journal of Biological Chemistry,271(22), 12687-12690. Kaplan, M. J., Ray, D., Mo, R. R., Yung, R. L., & Richardson, B. C. (2000). TRAIL (Apo2 ligand) and TWEAK (Apo3 ligand) mediate CD4+ T cell killing of antigen-presenting macrophages. The Journal of Immunology, 164(6), 2897-2904.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Lieferbar
Description	The RIK-2 monoclonal antibody recognizes human CD253, otherwise known as the TNF-related apoptosis inducing ligand (TRAIL) or tumor necrosis factor (ligand) superfamily member 10 (TNFSF10). TRAIL is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins, and contain a cytoplasmic "death domain", which activates the cell's apoptotic machinery. The RIK-2 antibody is reported to block cellular apoptosis induced by TRAIL.
Storage Temperature	4C
Formulation	Phosphate-buffered aqueous solution, ph7.2.
Preperation	The product should be stored undiluted at 4C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
Research Interest	Apoptosis
Format	SAFIRE (Functional)

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25611-25-100-datasheet.pdf

25611-25-100-safety-datasheet.pdf